Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
نویسندگان
چکیده
منابع مشابه
Long Noncoding RNAs
Ma Recent studies suggest that the majority of the human genome is transcribed, but only about 2% accounts for proteincoding exons. Long noncoding RNAs (lncRNAs) constitute a heterogenic class of RNAs that includes, for example, intergenic lncRNAs, antisense transcripts, and enhancer RNAs. Moreover, alternative splicing can lead to the formation of circular RNAs. In support of putative function...
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The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not been explored. Here we profiled the transcript...
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The recent advent of high-throughput approaches has revealed widespread transcription of the human genome, leading to a new appreciation of transcription regulation, especially from noncoding regions. Distinct from most coding and small noncoding RNAs, long noncoding RNAs (lncRNAs) are generally expressed at low levels, are less conserved and lack protein-coding capacity. These intrinsic featur...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2019
ISSN: 1940-087X
DOI: 10.3791/59233